Using single-cell genetic manipulation of electrical activity, MIT neuroscientists have discovered that neurons genetically rendered hyperactive (“noisiest”) survive better than normal neurons.

Neuronal survival is a key component in the success of cell replacement therapies in the brain. Current therapies have hit a roadblock because the vast majority of grafted cells do not survive and do not integrate into adult brain circuits.

The observation that the “noisiest” neurons have a survival advantage also helps explain the prevalence of epilepsy.