Breakdowns in DNA copying process lead to cancer, other diseases
April 23, 2013
The cell protein machines that copy DNA in a model organism pause frequently during this copying process, creating the potential for dangerous mutations to develop that can contribute to cancer and other diseases., University of York researchers have discovered.
The project focused on a bacterium called Escherichia coli, a powerful model for studying the DNA copying process.
“We have analyzed what causes most of these breakdowns and how, under normal circumstances, cells repair these broken copying machines, said Peter McGlynn, an Anniversary Professor in the University’s Department of Biology, who led the research team.
“Just as importantly, our work reveals that efficient repair of these breakdowns is very important to avoid corruption of the genetic code.”
The research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC).