University of Chicago researchers have discovered that many of the genetic variations that have enabled human populations to tolerate colder climates may also affect their susceptibility to metabolic syndrome, a cluster of related abnormalities such as obesity, elevated cholesterol levels, heart disease, and diabetes.

The researchers report that some genes associated with cold tolerance have a protective effect against the disease, while others increase disease risk. Genes that varied by climate included the lepin receptor, several involved in heat production, cholesterol metabolism, energy use, and blood glucose regulation.

University of Chicago Medical Center news release