Researchers develop new way to see single RNA molecules inside living cells

April 8, 2009 | Source: PhysOrg.com

A new type of fluorescent probe that can visualize single ribonucleic acid (RNA) molecules within live cells more easily has been developed by Georgia Institute of Technology researchers.

(Philip Santangelo)

(Philip Santangelo)

The probes, produced by attaching a few small fluorescent molecules called fluorophores to a modified nucleic acid sequence and combining the sequences with a protein, exhibit single-molecule sensitivity and allow the researchers to target and follow native RNA and non-engineered viral RNA in living cells.